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pentobarbital will minimize the extent or impact of capivasertib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Potent or reasonable CYP3A inducers lessen capivasertib exposure, which may lessen efficacy.pentobarbital will lower the level or outcome of alfuzosin by impacting hepatic/intestinal enzyme CYP3A4 m